Hemoglobin adducts, urinary metabolites and health effects in 2,4,6-trinitrotoluene exposed workers
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منابع مشابه
Hemoglobin adducts in workers exposed to nitrotoluenes.
Nitrotoluenes are important intermediates in the chemical industry. 2,6-Dinitrotoluene (26DNT), 2,4-dinitrotoluene (24DNT) and 2-nitrotoluene are carcinogenic in animals and possibly carcinogenic in humans. It is therefore important to develop methods to biomonitor workers exposed to such chemicals. Hemoglobin (Hb) adducts of nitroarenes are established markers of the biological effective dose....
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Benzidine (Bz) is a known human carcinogen. Several azo dyes have been synthesized with Bz. Bz can be metabolically released from azo dyes. In a group of Indian workers producing Bz and azo dyes the presence of hemoglobin (Hb) adducts was investigated. The following Hb adducts were identified and quantified by GC-MS: Bz, N-acetylbenzidine (AcBz), 4-aminobiphenyl (4ABP), aniline. 4ABP and anilin...
متن کاملMutagenic activity and metabolites in the urine of workers exposed to trinitrotoluene (TNT).
Urine samples taken after work and after a free weekend from 50 workers employed in various activities in a chemical plant manufacturing explosives were analysed. On the basis of hygienic surveys, the subjects were divided into three categories of exposure to trinitrotoluene (TNT). The urine analyses consisted of gas chromatographic identification of TNT and its two metabolites, 4-ADNT and 2-AD...
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Chlorobenzene is a colorless volatile compound widely used as an organic solvent or a chemical intermediate. There is, however, a potential risk for people engaged in the manufacture and the handling of this compound. The threshold limit value of the time-weighted average (TLV-TWA) for chlorobenzene in air has been set at 75 ppm (350 mg/m3).1) Animals exposed to chlorobenzene excrete this compo...
متن کاملDetermination of albumin and hemoglobin adducts in workers exposed to styrene and styrene oxide.
Hemoglobin and albumin adducts of the carcinogen styrene-7,8-oxide (SO) were measured in 48 workers exposed to both styrene and SO in a boat manufacturing plant. Personal exposures to both substances were measured repeatedly over the course of 1 year (styrene:0.9-235 mg/m3 with a mean of 64.3 mg/m3 for 48 subjects; S0: 13.4-525 mu g/m3 with a mean of 159 mu g/m3 for 20 subjects). Cysteine and c...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2005
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/bgi078